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Generic Name:ethinyl estradiol/norethindrone
Brand Names:Femhrt

Femhrt: Important Information

  • Femhrt increases the risk of developing endometrial hyperplasia, a condition that often causes cancer of the lining of the uterus. Intake of progestin such as norethindrone with Femhrt, lowers the risk of developing this condition. Visit your doctor for regular checkup and report any unusual vaginal bleeding right away. 
  • Treatment with estrogens and progestins over a long period of time may increase the risk of heart attack, stroke, breast cancer, and blood clots in the lungs or legs. Due to these risks, it is advisable to contact your doctor or healthcare provider to discuss your individual risks and benefits before taking an estrogen and progesterone combination long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) regarding the continuance of this treatment.
  • Undergo yearly physical examinations and examine your breasts for lumps on a monthly basis while taking Femhrt.
  • Do not take Femhrt if you are pregnant.

What is Femhrt

  • Ethinyl estradiol is a female sex hormone that is involved in the development and maintenance of the female reproductive system.
  • Norethindrone is a female hormone, usually called "progesterone." It is important for the regulation of ovulation and menstruation.
  • Together, ethinyl estradiol and norethindrone, are used to treat the symptoms of menopause such as feelings of warmth in the face, neck and chest, or sudden intense spells of heat and sweating ("hot flashes" or "hot flushes"), and to prevent thinning bones (osteoporosis).
  • Femhrt may also be used for purposes other than those listed in this medication guide.

What to Discuss Before Using Femhrt

  • Treatment with estrogens and progestins over a long period of time may increase the risk of heart attack, stroke, breast cancer, and blood clots in the lungs or legs. On account of these risks, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking an estrogen and progesterone combination long-term. You should also talk to your doctor or healthcare provider routinely (for example, every 3-6 months) with regard to the continuance of this treatment.
  • Do not take Femhrt without first consulting your doctor if you suffer from the following:
    • a circulation, bleeding, or blood-clotting disorder
    • undiagnosed, abnormal vaginal bleeding or
    • any type of breast, uterine, or hormone-dependent cancer.
  • Before taking Femhrt, inform your doctor if you have:
    • high blood pressure, angina, or heart disease
    • high levels of cholesterol or triglycerides in the blood
    • liver disease
    • kidney disease
    • asthma
    • epilepsy
    • migraines
    • diabetes
    • depression
    • gallbladder disease
    • uterine fibroids or
    • had a hysterectomy (uterus removed)
  • You may not be able to take Femhrt or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
  • Femhrt is in the FDA pregnancy category X. This means that the medication has been reported to cause birth defects in an unborn baby. Do not take Femhrt if you are pregnant or could become pregnant during treatment.
  • Femhrt may affect milk flow and milk composition. Do not take Femhrt without discussing with your doctor in case you are breast-feeding a baby.

Femhrt Dosage Method

  • Take Femhrt strictly as instructed by your doctor. In case you face difficulty in understanding these directions, do not hesitate to ask your pharmacist, nurse, or doctor to explain them to you.
  • Take each dose with a glass of water.
  • Try to take your doses at the same time each day.
  • It is important to take Femhrt regularly to derive maximum benefit.
  • Undergo yearly physical examination and check your breasts for lumps on a monthly basis while taking Femhrt.
  • Store Femhrt at room temperature away from moisture and heat.

Miss a dose: Problems?

  • Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose.
  • Do not take a double dose of this medication. 

Femhrt Overdose?

  • An overdose of Femhrt is unlikely to threaten life. Call an emergency room or poison control center for advice.
  • Symptoms of a Femhrt overdose might include nausea, vomiting, and vaginal bleeding.

Avoid During Treatment

  • There are no restrictions on food, beverages, or activity while taking Femhrt unless your doctor directs otherwise.

Femhrt Side Effects

  • Femhrt increases the risk of developing endometrial hyperplasia, a condition that may lead to cancer of the lining of the uterus. Taking a progestin, such as norethindrone, with ethinyl estradiol lowers the risk of developing this condition. Visit your doctor regularly and report any unusual vaginal bleeding right away. 
  • Treatment with estrogens and progestins long-term may increase the risk of heart attack, stroke, breast cancer, and blood clots in the lungs or legs. Because of these risks, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking an estrogen and progesterone combination long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment.
  • Stop taking Femhrt and seek emergency medical attention or contact your doctor immediately if you experience any of the following reactions:
    • an allergic reaction (difficulty in breathing, closing of the throat, swelling of the lips, tongue, face or hives)
    • shortness or breath or pain in chest
    • a painful, red, swollen leg
    • abnormal vaginal bleeding
    • pain, swelling, or tenderness in the abdomen
    • severe headache or vomiting, dizziness or changes in vision or speech
    • yellowing of the skin or eyes or
    • a lump in a breast
  • Other less serious side effects may be more likely to occur. Continue to take Femhrt and talk to your doctor if you experience:
    • nausea and vomiting
    • tenderness or enlargement of the breasts
    • swelling of your hands or feet
    • spotty darkening of the skin, particularly on the face
    • changes in your menstrual cycle, such as irregular bleeding or spotting
    • headache
    • depression or
    • vaginal yeast infections
  • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs to avoid while undergoing treatment

  • Before taking Femhrt, tell your doctor if you are taking any of the following medicines:
    • rifampin (Rifadin)
    • an anticoagulant (blood thinner) such as warfarin (Coumadin)
    • seizure medications such as phenytoin (Dilantin), carbamazepine (Tegretol), or phenobarbital (Luminal, Solfoton)
    • a thyroid medication such as levothyroxine (Synthroid, Levoxyl, Levothroid, and others)
    • insulin or an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase), and others or
    • tamoxifen (Nolvadex)
  • You may not be able to take Femhrt, or you may require a dosage adjustment or special monitoring during your treatment if you are taking any of the medicines listed above.
  • Drugs other than those listed here may also interact with Femhrt. Talk to your doctor and pharmacist before taking any prescriptions or over-the-counter medicines including vitamins, minerals, and herbal products.


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Femhrt 1/5 is a combination of hormones (estrogen and progestin) used to treat menopausal symptoms (e.g., hot flashes, vaginal dryness). Femhrt 1/5 is also used to prevent bone loss (osteoporosis) in people at high risk. If you are only being treated for vaginal menopause symptoms, products applied locally such as vaginal creams, tablets, or rings should be considered before products taken by mouth or absorbed through the skin. There are several medicines (e.g. raloxifene or bisphosphonates) that are safe and effective to prevent or treat bone loss. These medicines should be considered for use before estrogen/progestin HRT for osteoporosis. If you have other medical conditions as well and are prescribed estrogen/progestin HRT for more than one condition, consult your doctor about your treatment plan and its options.

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