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Generic Name: caffeine and ergotamine (cah FEEN and er GOH tah meen)
Brand Names: Cafatine, Cafergot, Cafetrate, Ercaf, Migergot, Wigraine

Cafergot : Important Information

  • Some medications may increase the risk of dangerously decreased blood flow to the brain, heart, or extremities when taken with caffeine and ergotamine. In rare but severe cases, gangrene or other serious problems can result. Do not take any other medications during treatment without first talking to your doctor.
  • Contact your doctor immediately if you experience numbness or tingling in the fingers or toes, chest pain, weakness of the legs, muscle pain in the arms or legs, pain in the chest, changes in heart rate, swelling or itching.
  • Do not take this medication if you are pregnant or if you could become pregnant during treatment. Thie medication is in the FDA pregnancy category X. This means that it can cause harm to an unborn baby. This medication can induce uterine contractions, which can result in abortion, and it can restrict blood flow to the fetus.
  • Do not use more than six tablets or two suppositories per headache. Do not use more than ten tablets or five suppositories in seven days. If your symptoms are not being adequately treated, talk to your doctor.

What is Cafergot

  • Caffeine and ergotamine both cause vasoconstriction (narrowing) of arteries and veins that supply blood to the head.
  • Used to prevent and to treat vascular headaches such as migraine and migraine-like headaches.

What to Discuss before Using

  • Some medications may increase the risk of dangerously decreased blood flow to the brain, heart, or extremities when taken with this medication. In rare but severe cases, gangrene or other serious problems can result. Do not take any other medications during treatment without first talking to your doctor.
  • Do not take this medication without first talking to your doctor if you have:
    • peripheral vascular disease or poor circulation
    • arteriosclerosis or "hardening of the arteries"
    • high blood pressure
    • heart disease
    • liver disease
    • kidney disease
    • a serious infection
  • You may not be able to take this medication, or you may require a special dosage or monitoring during treatment if you have any of the conditions listed above.
  • Do not take this medication if you are pregnant or if you could become pregnant during treatment. It is in the FDA pregnancy category X. This means that this medication can cause harm to an unborn baby. It can induce uterine contractions, which can result in abortion, and it can restrict blood flow to the fetus.
  • May pass into breast milk and harm a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Cafergot Dosage Method

  • Take exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
  • Take at the first sign of an attack.
  • For the oral tablets, two tablets should be taken at the first sign of a vascular headache; followed by one additional tablet every half hour if needed, up to six tablets per attack.
  • Use the rectal suppositories as directed by your doctor. One suppository should be administered at the first sign of a vascular headache; followed by one additional suppository after one hour if needed, up to two suppositories per attack.
  • Do not use more than six tablets or two suppositories per headache. Do not use more than ten tablets or five suppositories in seven days. If your symptoms are not being adequately treated, talk to your doctor.
  • Store at room temperature away from moisture and heat.

Miss a dose: Problems?

Since this medication is taken on an as-needed basis, missing a dose is not usually a problem.

Cafergot Overdose?

  • Seek emergency medical attention.
  • Symptoms of an overdose include nausea, vomiting, numbness in the fingers or toes, confusion, drowsiness, convulsions, and possibly death.

Avoid During Treatment

Do not take more than six tablets per headache. Do not take more than ten tablets in 7 days. If your symptoms are not being adequately treated, talk to your doctor.

Cafergot Side Effects

  • Stop taking this medication and seek emergency medical attention or contact your doctor immediately if you experience:
    • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
    • chest pain
    • numbness or tingling in the fingers or toes
    • muscle pain in the arms or legs
    • leg weakness
    • changes in heart rate
    • swelling
    • itching
  • Other, less serious side effects may also occur. Continue to take this medication and talk to your doctor if you experience nausea or vomiting
  • This medication may be habit forming when used for long periods of time. Larger doses may be needed for headache relief, and withdrawal effects may occur when therapy is stopped.
  • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs to avoid while undergoing treatment

  • Some medications may increase the risk of dangerously decreased blood flow to the brain, heart, or extremities when taken with this medication. In rare but severe cases, gangrene or other serious problems can result. The following drugs should not be taken with this medication or should be used only under the close supervision of a doctor:
    • another medication that contains an ergot compound such as Ergomar, D.H.E., or D.H.E. Nasal
    • another migraine headache medicine such as almotriptan (Axert), sumatriptan (Imitrex), zolmitriptan (Zomig), rizatriptan (Maxalt), or naratriptan (Amerge)--these medicines must not be taken within 24 hours of a dose of caffeine and ergotamine
    • a selective serotonin reuptake inhibitor (SSRI) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), sertraline (Zoloft), or paroxetine (Paxil)
    • a beta-blocker (which are used to treat high blood pressure, irregular heartbeats, and other heart conditions) such as carteolol (Cartrol), carvedilol (Coreg), labetalol (Normodyne, Trandate), nadolol (Corgard), pindolol (Visken), propranolol (Inderal), sotalol (Betapace), or timolol (Blocadren)
    • an HIV/ AIDS medicine such as amprenavir (Agenerase), delavirdine (Rescriptor), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), or saquinavir (Invirase, Fortovase)
    • the antibiotics erythromycin (Ery-Tab, E.E.S., E-Mycin, Eryc, others) or clarithromycin (Biaxin)
    • the antifungals medicines itraconazole (Sporanox) or ketoconazole (Nizoral)
    • nefazodone (Serzone)
    • cimetidine (Tagamet, Tagamet HB)
    • sibutramine (Meridia)
  • The use of this medication may be dangerous if you are taking any of the drugs listed above.
  • Drugs other than those listed here may also interact. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.


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Cafergot is the proprietary name of a medication consisting of ergotamine tartrate or ergoline and caffeine. It is currently available only in the suppository form for the acute treatment of vascular headaches, such as migraine headache. There are generic oral tablets with the same amounts of caffeine and ergotamine as were in the former Cafergot tablets. Now you can buy cheap cafergot tablets from our online prescription drugs pharmacy at a discount rate. Order for cafergot tablets online today and receive extra savings.

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Cafergot drug has various common side effects like dizziness, drowsiness, stomach upset, anxiety, and tremor. Cafergot drug effects should subside as your body adjusts to the medication. Cafergot medication should be taken after consulting a doctor and giving him in detail about patient’s medical history. Cafergot drug should be stored at room temperature and away from moisture and heat.

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