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Advair

Generic Name: Fluticasone and salmeterol (flew TIH cah sone and sal MEE teh rall)
Brand Names: Advair Diskus

Advair Diskus Inhaler : Important Information

• Data from a large study of people has shown a small but significant increased risk of asthma-related deaths. Discuss with your doctor the risks and benefits of using Advair Diskus Inhaler before starting treatment.
• Do not use Advair to treat an asthma attack that has already begun. It will not work fast enough to reverse your symptoms. Have another, faster-acting inhalation medication--such as albuterol (Ventolin, Proventil)--on hand to relieve asthma attacks.
• Do not use Advair more than it is prescribed.
• Use as directed, even when you are feeling better. Improvement in your condition may occur within 30 minutes of using a dose, however it may be one week or more before the full benefit of Advair inhaler is achieved. Talk to your doctor or other healthcare professional if your symptoms get worse or do not improve.
• It is very important that the inhaler is used properly, so that the medicine gets into the lungs. Talk to your doctor about proper inhaler use.
• Seek medical attention if you require more than your usual or more than the maximum amount of a short-acting asthma medication in a 24-hour period. An increased need for medication could be an early sign of a serious asthma attack.
• Do not use an inhaled, long-acting bronchodilator such as salmeterol (Serevent) or other inhaled steroid medicines during treatment with fluticasone and salmeterol inhalation unless otherwise directed by your doctor.

What is Advair

• Fluticasone is a steroid. It prevents the release of substances in the body that cause inflammation. Salmeterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing.
• Advair is used to prevent asthma attacks. It is used only to prevent asthma attacks, not to treat an attack already in progress. It will not work fast enough to give relief during an attack. Fluticasone and salmeterol inhalation is also used in the treatment of chronic obstructive pulmonary disease (COPD) associated with chronic bronchitis.

What to Discuss before Using Advair Inhaler

• Discuss with your doctor the risks and benefits of using Advair before starting treatment.
• Before using fluticasone and salmeterol, tell your doctor if you have:
  • a viral, bacterial, or fungal infection of any kind
  • ever had an allergic reaction to fluticasone (Flovent, Flonase) or salmeterol (Serevent)
  • heart disease or high blood pressure
  • epilepsy or another seizure disorder
  • diabetes
  • glaucoma
  • tuberculosis
  • an overactive thyroid (hyperthyroidism)
  • liver disease
• You may not be able to use advair medication or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
• Classified in the FDA pregnancy C. Therefore, it is unknown whether fluticasone and salmeterol inhalation will be harmful to an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment.
• It is not known whether medication can pass into breast milk. Do not use without first talking to your doctor if you are breast-feeding a baby.

Advair Diskus Dosage Method

• Use Advair Diskus exactly as directed by your doctor and read the information insert included with your inhaler.
• If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
• Usually used as one inhalation twice a day (morning and evening approximately 12 hours apart). Follow your doctor's instructions.
• Do not use more of this medication than is prescribed.
• Use fluticasone and salmeterol as directed, even when you are feeling better. Improvement in your condition may occur within 30 minutes of using a dose, however it may be one week or more before the full benefit is achieved.
• Do not use fluticasone and salmeterol to treat an asthma attack that has already begun.
• Do not use an inhaled, long-acting bronchodilator such as salmeterol (Serevent) or formoterol (Foradil) or an inhaled steroid medicine during treatment with fluticasone and salmeterol inhalation unless otherwise directed by your doctor.
• Continue to take any oral steroid (pills or liquid) that your doctor has prescribed. Fluticasone and salmeterol inhalation is not a substitute for an oral steroid.
• Store this medication at room temperature away from moisture and heat. The Diskus inhalation device is not reusable. Throw away the device 1 month after removal from the moisture-protective foil overwrap pouch or after all doses have been used (when the dose indicator reads "0"), whichever comes first. There are 60 doses per Diskus. Do not attempt to take the device apart.

Miss a dose: Problems?

Take the missed dose as soon as you remember. If it is almost time for the next regularly scheduled dose, skip the missed dose and use the next one as directed. Do not use a double dose of this medication.

Advair Diskus Overdose?

• Seek emergency medical attention if an overdose is suspected.
• Symptoms of a salmeterol and fluticasone overdose may include angina or chest pain, irregular or rapid heartbeats, seizures, tremor, weakness, headache, nausea, and vomiting.

Avoid During Treatment

• Avoid known items or activities that may worsen symptoms of asthma or bronchitis. Clean areas where dust or pet fur may aggravate your condition.
• Avoid exposing yourself to known sources of infection. Your immune system may not be strong enough to fight off an infection.

Advair Side Effects

• Serious side effects from fluticasone and salmeterol inhalation are not likely to occur.
• If you experience any of the following serious side effects, stop using fluticasone and salmeterol inhalation and seek emergency medical attention or notify your doctor immediately:
  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
  • chest pain or irregular heartbeats
  • numbness, tingling, or pain
  • a rash or unexplained open sores or bruising
  • worsening breathing or asthma symptoms
• Other, less serious side effects may be more likely to occur. Continue to take fluticasone and salmeterol inhalation and talk to your doctor if you experience:
  • dry mouth, nose, or throat after use
  • yeast (or another) infection in the mouth or throat (white patches)
  • hoarseness or deepening of the voice, cough, or sore throat
  • nausea, vomiting, or diarrhea
  • dizziness, headache, tremor, or nervousness
• Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs to avoid while undergoing treatment

Before taking advair inhaler, tell your doctor if you are taking any of the following medicines:

• another oral, nasal, or inhaled steroid
• a beta-blocker such as atenolol (Tenormin), metoprolol (Lopressor), propranolol (Inderal), and others
• a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate)
• a tricyclic antidepressant such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), and others
• a diuretic (water pill) such as hydrochlorothiazide (HydroDiuril, Esidrix, Oretic, Microzide), chlorothiazide (Diuril), furosemide (Lasix), and others
• caffeine (in food or medicines), a diet medicine, or a decongestant such as pseudoephedrine or phenylephrine
• a protease inhibitor such as ritonavir (Norvir)
• an antifungal medicine such as ketoconazole (Nizoral) or itraconazole (Sporanox)

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Advair Diskus is a combination of fluticasone propionate and salmeterol xinafoate. Advair Diskus is used as a maintenance treatment for children and adults with asthma. Advair Diskus is a combination of inhaled drugs that is used to treat asthma and chronic bronchitis. Advair medication does not work fast enough to give relief during an attack.

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Generic Advair Diskus are not available in the market. Since Advair Diskus contains salmeterol, it is always better not to be used with or within 2 weeks of discontinuing monoamine oxidase inhibitors or tricyclic antidepressants. Usage of long acting agents like salmeterol, an active ingredient in Advair Diskus, may increase the risk of asthma-related death. Therefore Advair Diskus inhaler should only be used in patients uncontrolled by other agents