Home >> RX Products >> Arava (Leflunomide)

Arava

Generic Name: leflunomide (oral) (leh FLEW no mide)
Brand Names: Arava

Arava : Important Information

Leflunomide is in the FDA pregnancy category X. There is an increased risk of birth defects and death of the unborn baby while taking leflunomide. Do not take this medication if you are pregnant or could become pregnant during treatment. Notify your doctor immediately if you think you have become pregnant during treatment. Birth control must be used during treatment with leflunomide. Discuss with your doctor the procedure for removing leflunomide from the body following treatment before becoming pregnant. Without the proper drug elimination procedure, it may take up to two years before leflunomide is at sufficiently low levels in the body so as to reduce the risk of harm to an unborn baby. It is not known whether leflunomide imposes an increased risk of fetal harm when taken by a man. Men wishing to father a child while taking leflunomide should discuss their options with their doctor.

What is Arava

• Affects the immune system and decreases inflammation.
• Used to reduce the signs and symptoms of rheumatoid arthritis, reduce damage to the joints caused by rheumatoid arthritis, and to improve physical function in people with rheumatoid arthritis.

What to Discuss before Using Arava

• Before taking Arava medication, tell your doctor if you have:
  • liver disease or a history of hepatitis
  • a history of significant alcohol use
  • kidney disease
  • an immune system disease
  • recently received a live vaccine
  • poor bone marrow function
  • a current or chronic infection
• You may not be able to take this medication, or you may require a special dosage or monitoring during your treatment if you have any of the conditions listed above.
• Leflunomide is in the FDA pregnancy category X. There is an increased risk of birth defects and death of the unborn baby while taking leflunomide. Do not take this medication if you are pregnant or could become pregnant during treatment. Notify your doctor immediately if you think you have become pregnant during treatment. Birth control must be used during treatment with leflunomide. Discuss with your doctor the procedure for removing leflunomide from the body following treatment before becoming pregnant. Without the proper drug elimination procedure, it may take up to two years before leflunomide is at sufficiently low levels in the body so as to reduce the risk of harm to an unborn baby. It is not known whether leflunomide imposes an increased risk of fetal harm when taken by a man. Men wishing to father a child while taking leflunomide should discuss their options with their doctor.
• It is not known whether this medication passes into breast milk. There is a potential for serious side effects in a nursing baby from leflunomide. Do not take leflunomide if you are breast-feeding a baby.

Arava Dosage Method

• Take exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
• Take each dose with a full glass of water.
• Can be taken with or without food or milk.
• It is important to take regularly to get the most benefit.
• Your doctor may want you to have blood tests or other medical evaluations while taking leflunomide to monitor side effects and progress.
• Store at room temperature away from moisture and heat.

Miss a dose: Problems?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take your next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.

Arava Overdose?

• Seek emergency medical attention if an overdose is suspected.
• Symptoms of an overdose may include diarrhea, abdominal pain, blood problems, and liver problems.

Avoid During Treatment

• Discuss with your doctor the use of alcohol while taking this medication. Alcohol and leflunomide can both be damaging to the liver.
• This medication can lower the activity of the immune system making you more susceptible to infection. Avoid contact with people who have colds, the flu, or other contagious illnesses. In addition, do not receive vaccines that contain a live strain of the virus (e.g., live oral polio vaccine) and avoid contact with individuals who have recently been vaccinated with a live virus.

Arava Side Effects

• If you experience any of the following serious side effects, stop taking this medication and seek medical treatment or contact your doctor immediately:
  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
  • changes in liver function (may be detected by blood tests or cause symptoms such as yellowing of the skin or eyes; pale colored stools or dark colored urine; unusual fatigue; or abdominal pain)
  • decreased bone marrow function or blood problems (may be detected by blood tests or cause symptoms such as extreme or unusual fatigue; easy bruising or bleeding; black, bloody or tarry stools; fever or chills; or signs of infection such as fever; chills, or sore throat)
  • skin rash
  • sores in the mouth
• Other, less serious side effects may be more likely to occur. Continue to take this medication and talk to your doctor if you experience:
  • headache
  • increased blood pressure
  • muscle aches
  • nausea
  • diarrhea
  • hair loss
• Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs to avoid while undergoing treatment

• Before taking this medication, tell your doctor if you are taking any of the following drugs:
  • cholestyramine (Questran, Prevalite, LoCHOLEST)
  • methotrexate (Rheumatrex)
  • rifampin (Rifadin, Rimactane)
• You may not be able to take this medication, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
• Drugs other than those listed here may also interact with leflunomide. Talk to your doctor and pharmacist before taking or using any other prescription or over-the-counter medicines , including vitamins, minerals, and herbal products.

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Arava (leflunomide) is a pyrimidine synthesis inhibitor that is available for oral administration as tablets containing 10, 20, or 100 mg of active drug. Arava is a disease-modifying antirheumatic prescription drug (DMARD), which helps to improve rheumatoid arthritis (RA) symptoms such as joint swelling and tenderness. But unlike many symptom relievers that only help relieve pain and swelling, Arava drug actually helps slow the progression of joint damage caused by rheumatoid arthritis.

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